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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Chlorogenic acid, Doxorubicin
Phytochemical Name Chlorogenic acid (PubChem CID: 1794427 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 318
Ref_1
Pair Name Chlorogenic acid, Doxorubicin
Disease Info [ICD-11: 2B51] Osteosarcoma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Cleavage CASP3 hsa836
Down-regulation Phosphorylation MAPK1 hsa5594
Down-regulation Phosphorylation MAPK3 hsa5595
Up-regulation Cleavage PARP1 hsa142
In Vitro Model U2OS Osteosarcoma Homo sapiens (Human) CVCL_0042
MG-63 Osteosarcoma Homo sapiens (Human) CVCL_0426
Result These findings firstly propose CGA as a promising chemosensitizer and cardioprotective agent in OS therapy, suggesting the p44/42 MAPK pathway as relevantly involved in CGA-mediated Doxo susceptibility.
03. Reference
No. Title Href
1 Chlorogenic Acid Enhances Doxorubicin-Mediated Cytotoxic Effect in Osteosarcoma Cells. Int J Mol Sci. 2021 Aug 10;22(16):8586. doi: 10.3390/ijms22168586. Click
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